UBI has developed a UBITh® vaccine for prevention of Foot-and-Mouth Disease (FMD), and this vaccine has performed superior or equivalent to licensed vaccines.

Exemplified by the recent outbreaks of FMD in Taiwan and the UK, the virus has caused a worldwide Pandemic, causing devastating economic losses. In the face of the pandemic, and the emergence of newly emerging technologies for differential diagnostics and marker vaccines of which UBI is a leader, there have been revisions in the international regulations for FMD control. There is now an increasing demand for state-of-art vaccines in the UK and in other normally FMD-free countries, in additional to the growing markets in countries that have previously been using FMD vaccines. This growing worldwide market for FMD vaccines gives our peptide-based product potential blockbuster status.

Our FMD vaccines are UBITh® marker vaccines that generate immune response that are readily distinguishable from those of infection, by the UBI ® FMDV ELISA diagnostic tests. The UBITh® vaccine for pigs has undergone successful infectious challenge trials in pigs at the National Institute of Animal Health in Taiwan, and the USDA Plum Island Animal Disease Center. Further trials in pigs are underway in Taiwan and Asia as part of global product registration procedures. A formulation for cattle is under development in Asia in collaboration with our Asian partner and in North America. The broadly protective nature of the UBI vaccines, the marker characteristic, and the safety and reproducibility of synthetic peptide immunogens provides significant competitive advantages over currently licensed inactivated virus vaccines.

Our FMD vaccines and our line of immunodiagnostic tests for FMDV work together synergistically in integrated national programs for disease control (Wang et al. Biologicals, 2001; 29:221-228). The UBI peptide-based vaccine/diagnostic system will be particularly attractive to FMD-free countries for defensive serosurveillance and for contingency plans for emergency vacciation in the event of an outbreak.